Senior Medical Director

Senior Medical Director – Contractor (Immunology / SLE Focus)

Belgium or Remote (Europe-based) – 6-Month Contract

Job Description

As Senior Medical Director (Contractor), you will play a key leadership role in the clinical development of small molecule programs, providing high-level medical and scientific expertise to ensure excellence in the planning, design, execution, monitoring, and reporting of clinical trials from Phase I through Phase III.

You will serve as the Medical Leader and Clinical Science Team (CST) representative, collaborating cross-functionally with internal teams, CROs, and external partners to drive clinical strategy and ensure patient safety, data integrity, and regulatory compliance.

This is a unique opportunity to contribute to life-changing therapies in immunology—particularly in Systemic Lupus Erythematosus (SLE)—within an innovative and dynamic environment.

Key Responsibilities:

• Serve as the Medical Leader for assigned clinical programs and as the CST representative.
• Act as the responsible physician for all medical aspects of clinical studies (Phase I–III).
• Monitor patient safety and data integrity as outlined in the Medical Monitoring and Oversight Plan.
• Evaluate individual patient data to ensure safety and well-being, following ICH/GCP and WHO/CanMED standards.
• Review and reconcile study-related listings, case report forms (CRFs), and data management plans.
• Provide medical input into CRO/vendor selection and maintain active collaboration with medical counterparts and KOLs.
• Contribute to regulatory documentation including CTAs, IBs, IMPDs, protocols, ICFs, and briefing materials.
• Develop and review study guidelines, lab manuals, and SOPs.
• Deliver training for CRAs, investigators, and study personnel; act as the central medical contact for study-related inquiries.
• Participate in safety management and contribute to risk mitigation and CAPA processes.
• Support statistical analysis planning (SAP), mock TLFs, and Clinical Study Reports (CSRs).
• Contribute to external publications and presentation of clinical study results.

Essential Requirements:

• MD
  with a minimum of
  10 years' experience
  in clinical research and the pharmaceutical industry.
• Proven track record as a
  Medical Director
  in
  Phase II–III clinical trials
  .
• Strong clinical and/or industry experience in
  Immunology
  (SLE experience highly desirable).
• Minimum
  3 years of medical practice experience
  .
• Deep scientific understanding and analytical mindset, ideally supported by post-doctoral or academic experience.
• Ability to lead cross-functional teams and
  influence in a matrix organization
  .
• Excellent communication and presentation skills, with
  native-level English fluency
  (written and spoken).
• Energetic, strategic, and proactive mindset with strong leadership capabilities.

Additional Insights:

• Start Date:
  ASAP
• Contract Duration:
  6 months (until March 2026)
• Minimum Commitment:
  80%
• Location:
  Flexible within Europe (some travel to Belgium required every other week or monthly)
• Therapeutic Focus:
  Immunology / SLE (Systemic Lupus Erythematosus)

Interested?

Send your CV to
Khanyi Mabena
at
k.-
, or reach out directly at

to learn more.